Open AccessEfficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil
Author(s) -
Traynard Pauline,
Ayral Géraldine,
Twarogowska Monika,
Chauvin Jonathan
Publication year - 2020
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.12500
Subject(s) - workflow , computer science , visualization , data mining , software , nonmem , graphical user interface , set (abstract data type) , computation , population , programming language , database , demography , sociology
MonolixSuite is a software widely used for model‐based drug development. It contains interconnected applications for data visualization, noncompartmental analysis, nonlinear mixed effect modeling, and clinical trial simulations. Its main assets are ease of use via an interactive graphical interface, computation speed, and efficient parameter estimation even for complex models. This tutorial presents a step‐by‐step pharmacokinetic (PK) modeling workflow using MonolixSuite, including how to visualize the data, set up a population PK model, estimate parameters, and diagnose and improve the model incrementally.