Open AccessApplications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities
Author(s) -
Bradshaw Erica L.,
Spilker Mary E.,
Zang Richard,
Bansal Loveleena,
He Handan,
Jones Rhys D.O.,
Le Kha,
Penney Mark,
Schuck Edgar,
Topp Brian,
Tsai Alice,
Xu Christine,
Nijsen Marjoleen J.M.A.,
Chan Jason R.
Publication year - 2019
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.12463
Subject(s) - systems pharmacology , context (archaeology) , perspective (graphical) , management science , computer science , data science , pharmacology , engineering ethics , medicine , drug , engineering , biology , artificial intelligence , paleontology
Quantitative systems pharmacology (QSP) approaches have been increasingly applied in the pharmaceutical since the landmark white paper published in 2011 by a National Institutes of Health working group brought attention to the discipline. In this perspective, we discuss QSP in the context of other modeling approaches and highlight the impact of QSP across various stages of drug development and therapeutic areas. We discuss challenges to the field as well as future opportunities.