Open AccessNonlinear Mixed‐Effects Model Development and Simulation Using nlmixr and Related R Open‐Source Packages
Author(s) -
Fidler Matthew,
Wilkins Justin J.,
Hooijmaijers Richard,
Post Teun M.,
Schoemaker Rik,
Trame Mirjam N.,
Xiong Yuan,
Wang Wenping
Publication year - 2019
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.12445
Subject(s) - nonmem , nonlinear system , open source , open source software , computer science , software , mixed model , mathematics , pharmacokinetics , pharmacology , machine learning , medicine , physics , programming language , quantum mechanics
nlmixr is a free and open‐source R package for fitting nonlinear pharmacokinetic (PK) , pharmacodynamic (PD), joint PK‐ PD , and quantitative systems pharmacology mixed‐effects models. Currently, nlmixr is capable of fitting both traditional compartmental PK models as well as more complex models implemented using ordinary differential equations. We believe that, over time, it will become a capable, credible alternative to commercial software tools, such as NONMEM , Monolix, and Phoenix NLME .