Open AccessA Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab
Author(s) -
Stader Felix,
Penny Melissa A.,
Siccardi Marco,
Marzolini Catia
Publication year - 2019
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.12399
Subject(s) - physiologically based pharmacokinetic modelling , computer science , pharmacokinetics , matlab , drug , coding (social sciences) , computational biology , management science , medical physics , pharmacology , medicine , programming language , engineering , biology , mathematics , statistics
Physiologically‐based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly. However, the coding of a PBPK model in a mathematical programming language can be challenging. This tutorial illustrates how to build a whole‐body PBPK model in Matlab to answer specific pharmacological questions involving drug disposition and magnitudes of drug–drug interactions in different patient populations.