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I was delighted to participate as a speaker and panel discussant at the 2018 American Conference on Pharmacometrics in a session devoted to dialogue between "pharmacometric modelers" and "statisticians". In the current perspective I reprise the major points of my talk, which addressed the possibility of drawing valid causal inferences from observational data. I augment this reprise with brief remarks comparing diagrammatic conventions in pharmacometrics to those used in formal causal diagrams. This article is protected by copyright. All rights reserved.

Causa Nostra: The Potentially Legitimate Business of Drawing Causal Inferences From Observational Data