Open AccessModel‐Informed Assessment of Anti‐Infectives for Young Children in Low‐ and Middle‐Income Countries
Author(s) -
Zhao Ping,
Arm Jonathan,
Ma LyouFu,
Ward Stephen,
Hermann David,
Wesche David,
Hartman Dan,
Kern Steven
Publication year - 2019
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.12393
Subject(s) - medicine , environmental health , population , developing country , malaria , child mortality , intensive care medicine , pediatrics , economic growth , immunology , economics
Infectious diseases continue to threaten the lives of young children in low and middle-income countries (LMICs). Pediatric assessment of anti-infectives for these children should be initiated early. This assessment can center around an iterative dose-selection process that is informed by an integrated prediction platform based on physiologically-based pharmacokinetic and pharmacodynamic (PBPK-PD) models. This article is protected by copyright. All rights reserved.