Open AccessModeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond‐Forming Oxidoreductase A‐Like Protein ( DsbA‐L ) Polymorphism on the Weight Status
Author(s) -
Oniki Kentaro,
Watanabe Takehisa,
Kudo Miku,
Izuka Tomoko,
Ono Tatsumasa,
Matsuda Kazuki,
Sakamoto Yuki,
Nagaoka Katsuya,
Imafuku Tadashi,
Ishima Yu,
Watanabe Hiroshi,
Maruyama Toru,
Otake Koji,
Ogata Yasuhiro,
Saruwatari Junji
Publication year - 2018
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.12292
Subject(s) - nonalcoholic fatty liver disease , body mass index , medicine , metabolic syndrome , fatty liver , hypertriglyceridemia , gastroenterology , obesity , endocrinology , bioinformatics , disease , biology , cholesterol , triglyceride
Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity. Disulfide bond‐forming oxidoreductase A‐like protein (DsbA‐L) is known to be a key molecule in protection against obesity and obesity‐induced inflammation. In the present study, we used a modeling and simulation approach in an attempt to develop body mass index (BMI) and BMI‐based NAFLD prediction models incorporating the DsbA‐L polymorphism to predict the BMI and NAFLD in 341 elderly subjects. A nonlinear mixed‐effect model best represented the sigmoidal relationship between the BMI and the logit function of the probability of NAFLD prevalence. The final models for BMI and NAFLD showed that DsbA‐L rs1917760 polymorphism, age, and gender were associated with the BMI, whereas gender, patatin‐like phospholipase 3 rs738409 polymorphism, HbA1c, and high‐density and low‐density lipoprotein cholesterol levels were associated with the risk of NAFLD. This information may aid in the genetic‐based prevention of obesity and NAFLD in the general elderly population.