Open AccessTranslational Systems Pharmacology Studies in Pregnant Women
Author(s) -
Quinney Sara K.,
Gullapelli Rakesh,
Haas David M.
Publication year - 2018
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.12269
Subject(s) - pregnancy , bioinformatics , fetus , medicine , systems pharmacology , adaptation (eye) , systems biology , computational biology , physiology , biology , neuroscience , pharmacology , drug , genetics
Pregnancy involves rapid physiological adaptation and complex interplay between mother and fetus. New analytic technologies provide large amounts of genomic, proteomic, and metabolomics data. The integration of these data through bioinformatics, statistical, and systems pharmacology techniques can improve our understanding of the mechanisms of normal maternal physiologic changes and fetal development. New insights into the mechanisms of pregnancy‐related disorders, such as preterm birth (PTB), may lead to the development of new therapeutic interventions and novel biomarkers.