Open AccessA Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics
Author(s) -
Duffull SB
Publication year - 2016
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.12148
Subject(s) - falsifiability , systems pharmacology , clinical pharmacology , management science , computer science , epistemology , systems biology , engineering ethics , computational biology , pharmacology , medicine , biology , philosophy , engineering , drug
The framework for systems pharmacology style models does not naturally sit with the usual scientific dogma of parsimony and falsifiability based on deductive reasoning. This does not invalidate the importance or need for overarching models based on pharmacology to describe and understand complicated biological systems. However, it does require some consideration on how systems pharmacology fits into the overall scientific approach.