Open AccessA Tutorial on RxODE: Simulating Differential Equation Pharmacometric Models in R
Author(s) -
Wang W,
Hallow KM,
James DA
Publication year - 2016
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.12052
Subject(s) - computer science , ordinary differential equation , coding (social sciences) , computational science , differential equation , simulation , mathematics , mathematical analysis , statistics
This tutorial presents the application of an R package, RxODE, that facilitates quick, efficient simulations of ordinary differential equation models completely within R. Its application is illustrated through simulation of design decision effects on an adaptive dosing regimen. The package provides an efficient, versatile way to specify dosing scenarios and to perform simulation with variability with minimal custom coding. Models can be directly translated to Rshiny applications to facilitate interactive, real‐time evaluation/iteration on simulation scenarios.