Open AccessEffect of single‐nucleotide polymorphisms in ADH 1B , ADH 4 , ADH 1C , OPRM 1 , DRD 2 , BDNF , and ALDH 2 genes on alcohol dependence in a Caucasian population
Author(s) -
Katsarou MarthaSpyridoula,
Karakonstantis Konstantinos,
Demertzis Nikolaos,
Vourakis Emmanouil,
Skarpathioti Aspasia,
Nosyrev Aleksandr E.,
Tsatsakis Aristidis,
Kalogridis Theodoris,
Drakoulis Nikolaos
Publication year - 2017
Publication title -
pharmacology research and perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.975
H-Index - 27
ISSN - 2052-1707
DOI - 10.1002/prp2.326
Subject(s) - population , allele , single nucleotide polymorphism , rs6265 , allele frequency , mutant , snp , genetics , biology , medicine , genotype , polymorphism (computer science) , gene , environmental health
Alcohol is a frequently used addictive substance worldwide. Aim of this study is to determine the frequency distribution of SNP s within ADH 1B , ADH 4 , ADH 1C , ALDH 2, BDNF , OPRM 1 , and DRD 2 genes in a southeastern European Caucasian population from Greece. For this purpose samples of 1276 volunteers were analyzed after deidentification and anonymization. The allele distribution of the examined polymorphisms in the present Greek population cohort was as follows: rs1229984 ( ADH 1B ): GG (wt) = 64.14%, GA = 29.86%, AA = 4.00%; rs1693482 ( ADH 1C ): CC (wt) = 57.45%, CT = 36.76%, TT = 5.80%; rs1799971 ( OPRM 1 ): AA (wt) = 72.43%, AG = 28.72%, GG = 1.89%; rs1800497 ( DRD 2 ): CC (wt) = 70.84%, CT = 27.18%, TT = 1.98%; rs1800759 ( ADH 4 ): CC (wt) = 34.25%, CA = 48.12%, AA = 17.63%; rs6265 ( BDNF ): GG (wt) = 65.99%, GA = 31.02%, AA = 2.99%; and rs671 ( ALDH 2 ): GG (wt) = 99.84% GA = 0.16%, AA = 0.00%. Mutant rs1229984 allele A was ~6.5× more frequent in the Greek than in the European population. Mutant rs1693482 allele T was ~1.7× more frequent in the European than in the Greek population. Mutant alleles for polymorphisms rs1800759 and rs1799971 show similar frequencies in both northern and southern Europeans. One rs671 mutant A allele was detected in the Greek population (0.08%). The mutant rs1800497 allele T was ~1.2× more frequent in the European than in the Greek population and the mutant rs6265 allele A was ~1.1× more frequent in the European than in the Greek population. An alcohol addiction‐specific algorithm was generated ( TGS ) that may predict alcohol addiction prevalence in a population. According to our findings, the analyzed Southeastern population may differ genetically from north Europeans due to influences from neighboring Asian and African populations and a calculated TGS score >50 indicates individuals with low susceptibility to develop alcohol addiction.