Open AccessSevere acute respiratory syndrome coronavirus 2‐induced multisystem inflammatory syndrome in children
Author(s) -
Feng Zhiguan,
Bao Yanmin,
Yang Yonghong,
Zheng Yuejie,
Shen Kunling
Publication year - 2020
Publication title -
pediatric investigation
Language(s) - English
Resource type - Journals
ISSN - 2574-2272
DOI - 10.1002/ped4.12225
Subject(s) - medicine , pathophysiology , systemic inflammatory response syndrome , kawasaki disease , intensive care unit , respiratory system , coronavirus , disease , intensive care medicine , multisystem disease , covid-19 , immunology , pediatrics , sepsis , infectious disease (medical specialty) , artery
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐induced multisystem inflammatory syndrome in children (MIS‐C) is a life‐threatening illness that has been reported in the United States and Europe. It affects multiple organ systems and often requires patient admission to an intensive care unit. Although some features of MIS‐C overlap with Kawasaki disease, MIS‐C is more common among older children and adolescents, more often affects cardiovascular and gastrointestinal systems, and more frequently presents with elevated inflammatory markers. Rapid and complete clinical recovery is possible in nearly all patients following immunomodulation therapy. Thus far, MIS‐C pathophysiology and long‐term prognosis are not sufficiently clear; further studies are needed.