English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Importance  Regional clonal replacements of methicillin‐resistant  Staphylococcus aureus  ( MRSA ) are common. It is necessary to understand the clonal and drug resistance changes in specific areas.    Objective  To evaluate the clonal and drug resistance dynamics of  MRSA  in Chinese children from 2010 to 2017.    Methods   MRSA  was isolated from patients in Beijing Children's Hospital from 2010 to 2013 and from 2016 to 2017. The molecular characteristics and antibiotic resistance were determined.    Results  In total, 211  MRSA  isolates were collected, and 104 isolates were classified as community‐associated  MRSA  ( CA ‐ MRSA ).  ST 59‐ SCC  mec   IV  was the most prevalent type in both  CA ‐ MRSA  (65.4%) and healthcare‐ associated‐ MRSA  ( HA ‐ MRSA ) (46.7%).  ST 239‐ SCC  mec   III  accounted for 21.5% of all  HA ‐ MRSA , which were not detected in 2016, and only three isolates were detected in 2017. The  pvl  gene carrying rate of  CA ‐  MRSA  was significantly higher than that of  HA ‐ MRSA  (42.3% vs. 29.0%,  P  = 0.0456). Among  CA ‐ MRSA , resistance rate to all tested antibiotics excluding chloramphenicol remained stable over the periods of 2010–2013 and 2016–2017.  HA ‐ MRSA  displayed an overall trend of decreased resistance to oxacillin, gentamicin, tetracycline, ciprofloxacin, and rifampin, and increased resistance to chloramphenicol, consistent with the difference of antibiotic resistance patterns between  ST 59‐ SCC  mec   IV  and  ST 239‐ SCC  mec   III  isolates. Vancomycin minimal inhibitory concentration ( MIC ) creep was found in the study period in all  MRSA  and  ST 59‐ SCC  mec   IV  isolates.    Interpretation   ST 59‐ SCC  mec   IV  has spread to hospitals and replaced the traditional  ST 239‐ SCC  mec   III  clone, accompanied by changes in drug resistance. Furthermore, vancomycin  MIC  creep indicated that the rational use of antibiotics should be seriously considered.

Clonal and drug resistance dynamics of methicillin‐resistant Staphylococcus aureus in pediatric populations in China