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Futility versus utility of marrow assessment in initial Ewing sarcoma staging workup
Author(s) -
Anderson Peter M.
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25246
Subject(s) - medicine , bone marrow , sarcoma , biopsy , radiology , ewing's sarcoma , cancer , pathology
In the early days of Ewing sarcoma staging work-ups for chemotherapy planning and risk stratification in clinical trials, bone involvement with the primary tumor and/or metastases was assessed with (a) 99mTc-MDP bone scan which detect metastatic bone lesions that cause remodeling, and (b) bone marrow aspiration and biopsy. Currently there are many non-invasive methods to assess bone and/or marrow involvement including 99mTc-MDP bone scan 18FDG-PET-CT, and MRI 1. The study by Newman et al. demonstrated that 0/57 patients without osseous metastases on 18FDG PET-CT had bone marrow involvement 1.