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New scope for synthesis of divinyl ether and maleic anhydride copolymer with narrow molecular mass distribution
Author(s) -
Volkova I. F.,
Gorshkova M. Yu.,
Ivanov P. E.,
Stotskaya L. L.
Publication year - 2002
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.234
Subject(s) - molecular mass , gel permeation chromatography , copolymer , maleic anhydride , monomer , molar mass distribution , ether , polymer chemistry , size exclusion chromatography , materials science , permeation , organic chemistry , chemistry , polymer , membrane , biochemistry , enzyme
Abstract The alternating copolymer of divinyl ether and maleic anhydride (DIVEMA) possesses diverse biological activity and uses for production of drug delivery systems. DIVEMA's biological effects are determined by molecular mass, therefore it is necessary to have information about copolymer molecular mass and its distribution. A direct method for gel permeation chromatography analysis of DIVEMA molecular mass characteristics in aqua solution without any preliminary modification was developed. The effect of a number of factors (the concentration of monomers and their ratios, the concentration of initiator, the nature of the solvents) on DIVEMA's solution properties and molecular mass distribution was studied by gel permeation chromatography and viscometry. The approach to synthesis of DIVEMA with narrow molecular mass distribution was designed. The substantial influence of water on DIVEMA molecular mass characteristics was determined. The proposal was made that water may play a part in the formation of charge‐transfer complexes playing a significant role in copolymerization. Copyright © 2003 John Wiley & Sons, Ltd.