Open AccessChromatography‐Free Multicomponent Synthesis of Thioureas Enabled by Aqueous Solution of Elemental Sulfur
Author(s) -
Németh András Gy.,
Szabó Renáta,
Domján Attila,
Keserű György M.,
ÁbrányiBalogh Péter
Publication year - 2021
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.202000250
Subject(s) - polysulfide , sulfur , chemistry , aqueous solution , size exclusion chromatography , filtration (mathematics) , functional group , inorganic chemistry , organic chemistry , chromatography , polymer , statistics , mathematics , electrode , electrolyte , enzyme
The development of a new three‐component chromatography‐free reaction of isocyanides, amines and elemental sulfur allowed us the straightforward synthesis of thioureas in water. Considering a large pool of organic and inorganic bases, we first optimized the preparation of aqueous polysulfide solution from elemental sulfur. Using polysulfide solution, we were able to omit the otherwise mandatory chromatography, and to isolate the crystalline products directly from the reaction mixture by a simple filtration, retaining the sulfur in the solution phase. A wide range of thioureas synthesized in this way confirmed the reasonable substrate and functional group tolerance of our protocol.