Open AccessUnveiling the reaction process of the amine in direct amidation of aromatic ketones in H 2 O
Author(s) -
He Fangjun,
Qu Rumeng,
Su Jie,
Du Muyao,
Liu Junqiang,
Chen Yiping,
Wang Bo
Publication year - 2020
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.202000178
Subject(s) - amine gas treating , chemistry , yield (engineering) , catalysis , aromatic amine , organic chemistry , base (topology) , combinatorial chemistry , materials science , mathematical analysis , mathematics , metallurgy
In the classical amidation between aromatic ketones and amines, 2.0 equivalents of amines are necessarily required to gain satisfying yields. The specific role of the amine in the direct amidation already puzzled us for a long time. In this work, we disclosed that the amine acts as both reactant and catalyst. Specifically, the determination of reaction intermediates revealed the full mechanism, based on which, the introduction of one equivalent base in the amidation is showcased here that a high yield (∼95 %) can be afforded using only 1.1 equiv. of amine.