Open AccessThe Allylic Alkylation of Ketone Enolates
Author(s) -
Junk Lukas,
Kazmaier Uli
Publication year - 2020
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.202000175
Subject(s) - ketone , tsuji–trost reaction , alkylation , palladium , allylic rearrangement , chemistry , catalysis , organic chemistry , combinatorial chemistry
The palladium‐catalyzed allylic alkylation of non‐stabilized ketone enolates was thought for a long time to be not as efficient as the analogous reactions of stabilized enolates, e. g. of malonates and β‐ketoesters. The field has experienced a rapid development during the last two decades, with a range of new, highly efficient protocols evolved. In this review, the early developments as well as current methods and applications of palladium‐catalyzed ketone enolate allylations will be discussed.