Open AccessInvestigation of Parameters that Affect Resin Swelling in Green Solvents
Author(s) -
AmadiKamalu Chidi,
Clarke Holly,
McRobie Matthew,
Mortimer James,
North Michael,
Ran Yanrui,
Routledge Anne,
Sibbald Dani,
Tickias Matthew,
Tse Kai,
Willway Helen
Publication year - 2020
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.202000030
Subject(s) - swelling , solubility , polystyrene , hildebrand solubility parameter , chemical engineering , peg ratio , polymer chemistry , chemistry , materials science , organic chemistry , polymer , composite material , finance , engineering , economics
The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis.