English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Malononitrile is a useful reagent for multicomponent reactions with hundreds of methods developed. In this paper, we suggest α‐(cyano)‐ o ‐tolunitrile (homophtalonitrile) to work as a vinylogous malononitrile. Thus, a organocatalytic pseudo‐three‐component reaction of homopthalonitrile (2 equiv) and  o ‐hydroxybenzaldehyde, leading to the diastereoselective formation of 5‐amino‐12 H ‐chromeno[2,3‐c]isoquinolin‐12‐yl)(cyano)methyl)benzonitriles, was discovered. The possibility to employ other nucleophiles was demonstrated for indoles, and a sequential three‐component reaction of homophtalonitrile,  o ‐hydroxybenzaldehyde, and (aza)indole, giving 12‐(1 H ‐Indol‐3‐yl)‐12 H ‐chromeno[2,3‐ c ]isoquinolin‐5‐amines, was developed. The photophysical properties of the synthesized compounds have been studied, revealing high fluorescence quantum yields (42–70 %) for indol‐3‐yl substituted 12 H ‐chromeno[2,3‐ c ]isoquinolin‐5‐amines and reversible fluorescence quenching under acidic conditions.

chemistryopen

Homophtalonitrile for Multicomponent Reactions: Syntheses and Optical Properties of  o ‐Cyanophenyl‐ or Indol‐3‐yl‐Substituted Chromeno[2,3‐ c ]isoquinolin‐5‐Amines