Open AccessSynthesis and Characterization of Novel Fluoro‐glycosylated Porphyrins that can be Utilized as Theranostic Agents
Author(s) -
Arja Katriann,
Elgland Mathias,
Appelqvist Hanna,
Konradsson Peter,
Lindgren Mikael,
Nilsson K. Peter R.
Publication year - 2018
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201800020
Subject(s) - photodynamic therapy , characterization (materials science) , chemistry , combinatorial chemistry , cancer therapy , nanotechnology , moiety , small molecule , cancer , materials science , biochemistry , organic chemistry , medicine
Small molecules with modalities for a variety of imaging techniques as well as therapeutic activity are essential, as such molecules render opportunities to simultaneously conduct diagnosis and targeted therapy, so called theranostics. In this regard, glycoporphyrins have proven useful as theranostic agents towards cancer, as well as noncancerous conditions. Herein, the synthesis and characterization of heterobifunctional glycoconjugated porphyrins with two different sugar moieties, a common monosaccharide at three sites, and a 2‐fluoro‐2‐deoxy glucose (FDG) moiety at the fourth site are presented. The fluoro‐glycoconjugated porphyrins exhibit properties for multimodal imaging and photodynamic therapy, as well as specificity towards cancer cells. We foresee that our findings might aid in the chemical design of heterobifunctional glycoconjugated porphyrins that could be utilized as theranostic agents.