Open AccessSpecific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry
Author(s) -
Brand Christian,
Iacono Pasquale,
PérezMedina Carlos,
Mulder Willem J. M.,
Kircher Moritz F.,
Reiner Thomas
Publication year - 2017
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201700105
Subject(s) - tetrazine , cyclooctene , nanoparticle , click chemistry , chemistry , nanotechnology , liposome , combinatorial chemistry , materials science , organic chemistry , catalysis
Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron‐demand Diels–Alder reaction. Inspired by recent accomplishments in pre‐targeted imaging using tetrazine‐ trans ‐cyclooctene click chemistry, we synthesized 89 Zr‐labeled trans ‐cyclooctene‐functionalized liposomal nanoparticles, which were validated on a tetrazine‐appended polydopamine‐coated CoCrMo surface. In efforts to ultimately translate this new material to biomedical applications, we compared the ability of 89 Zr‐TCO–liposomal nanoparticles ( 89 Zr‐TCO‐LNP) to be immobilized on the tetrazine surface to the control suspensions of non‐TCO functionalized 89 Zr‐liposomal nanoparticles. Ultimately, this platform technology could result in a systemic decrease of the radiotherapeutic dose deposited in non‐targeted tissues by specific removal of long‐circulating liposomal radiopharmaceuticals from the blood pool.