Open AccessSilver(I)‐Catalyzed Intramolecular Cyclizations of Epoxide‐Propargylic Esters to 1,4‐Oxazine Derivatives
Author(s) -
Li PengHua,
Yang JinMing,
Wei Yin,
Shi Min
Publication year - 2017
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201600123
Subject(s) - intramolecular force , epoxide , chemistry , cycloisomerization , domino , ring (chemistry) , catalysis , sigmatropic reaction , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry
An interesting silver(I)‐catalyzed, one‐pot intramolecular cyclization of epoxide‐propargylic esters is described. A variety of 1,4‐oxazine derivatives were obtained through a novel domino sequence, including three‐membered ring‐opening, 3,3‐sigmatropic rearrangement, 6‐ exo ‐cycloisomerization and subsequent intramolecular elimination in moderate yields under mild conditions.