Open AccessHyperbranched Polyglycerol‐Induced Porous Silica Nanoparticles as Drug Carriers for Cancer Therapy In Vitro and In Vivo
Author(s) -
Yang Yang,
Wang Anhe,
Wei Qiang,
Schlesener Cathleen,
Haag Rainer,
Li Qi,
Li Junbai
Publication year - 2017
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201600072
Subject(s) - mesoporous silica , biocompatibility , drug delivery , nanoparticle , biocompatible material , in vivo , nanotechnology , drug carrier , materials science , cancer therapy , chemistry , biodegradation , mesoporous material , biomedical engineering , organic chemistry , cancer , medicine , microbiology and biotechnology , biology , catalysis
Mesoporous silica‐based nanoparticles are generally accepted as a potential platform for drug loading with a lot of advantages, except for their complex purification procedures and structures that are difficult to decompose. In this work, biocompatible hyperbranched polyglycerol is introduced to synthesize mesoporous silica nanoparticles (MSNs). The materials possess good biocompatibility, controlled release, and biodegradability. They also show passive targeting capability through the enhanced permeability and retention effect and can be excreted from the biological system. The method avoids the needs to employ traditional surfactants and complicated purified procedures, which make these MSNs an efficient delivery system for cancer therapy.