Open AccessChemical O‐Glycosylations: An Overview
Author(s) -
Das Rituparna,
Mukhopadhyay Balaram
Publication year - 2016
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201600043
Subject(s) - glycobiology , glycosylation , glycosidic bond , chemistry , regioselectivity , oligosaccharide , glycosyl , nanotechnology , biochemical engineering , organic chemistry , biochemistry , engineering , glycan , materials science , catalysis , glycoprotein , enzyme
Abstract The development of glycobiology relies on the sources of particular oligosaccharides in their purest forms. As the isolation of the oligosaccharide structures from natural sources is not a reliable option for providing samples with homogeneity, chemical means become pertinent. The growing demand for diverse oligosaccharide structures has prompted the advancement of chemical strategies to stitch sugar molecules with precise stereo‐ and regioselectivity through the formation of glycosidic bonds. This Review will focus on the key developments towards chemical O‐glycosylations in the current century. Synthesis of novel glycosyl donors and acceptors and their unique activation for successful glycosylation are discussed. This Review concludes with a summary of recent developments and comments on future prospects.