Open AccessA Chromogenic Probe for the Selective Recognition of Sarin and Soman Mimic DFP
Author(s) -
El Sayed Sameh,
Pascual Lluís,
Agostini Alessandro,
Martínez-Máñez Ramón,
Sancenón Félix,
Costero Ana M.,
Parra Margarita,
Gil Salvador
Publication year - 2014
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201402014
Subject(s) - sarin , tabun , soman , nerve agent , chemistry , chromogenic , moiety , fluoride , acetonitrile , combinatorial chemistry , organic chemistry , chromatography , inorganic chemistry , acetylcholinesterase , enzyme
The synthesis, characterization and sensing features of a novel probe 1 for the selective chromogenic recognition of diisopropylfluorophosphate (DFP), a sarin and soman mimic, in 99:1 ( v / v ) water/acetonitrile and in the gas phase is reported. Colour modulation is based on the combined reaction of phosphorylation of 1 and fluoride‐induced hydrolysis of a silyl ether moiety. As fluoride is a specific reaction product of the reaction between DFP and the −OH group, the probe shows a selective colour modulation in the presence of this chemical. Other nerve agent simulants, certain anions, oxidant species and other organophosphorous compounds were unable to induce colour changes in 1 . This is one of the very few examples of a selective detection, in solution and in the gas phase, of a sarin and soman simulant versus other reactive derivatives such as the tabun mimic diethylcyanophosphate (DCNP).