Open AccessRoom Temperature, Metal‐Free Arylation of Aliphatic Alcohols
Author(s) -
Ghosh Raju,
Lindstedt Erik,
Jalalian Nazli,
Olofsson Berit
Publication year - 2014
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201402006
Subject(s) - aryl , alkyl , chemistry , metal , organic chemistry , combinatorial chemistry
Diaryliodonium salts are demonstrated as efficient arylating agents of aliphatic alcohols under metal‐free conditions. The reaction proceeds at room temperature within 90 min to give alkyl aryl ethers in good to excellent yields. Aryl groups with electron‐withdrawing substituents are transferred most efficiently, and unsymmetric iodonium salts give chemoselective arylations. The methodology has been applied to the formal synthesis of butoxycaine.