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The determination of steric purity of amines and amino acids by gas chromatography and mass spectrometry
Author(s) -
Wiecek C.,
Halpern B.,
Sargeson A. M.,
Duffield A. M.
Publication year - 1979
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210140509
Subject(s) - diastereomer , chemistry , steric effects , mass spectrometry , enantiomer , chromatography , gas chromatography , chloride , gas chromatography–mass spectrometry , chemical ionization , amino acid , organic chemistry , medicinal chemistry , ionization , ion , biochemistry
Abstract Amines and amino acids have been condensed with a mixture of N‐TFA‐ R ‐prolyl chloride and n ‐TFA‐ S ‐[1‐ 2 H]‐prolyl chloride and the resulting four diastereoisomers have been separated by gas chromatography into two peaks. The amount of each diastereoisomer formed was then determined by chemical ionization mass spectrometry. The steric purity of the enantiomeric mixture can be calculated from these values. The method is not dependent on the diastereoisomer formation going to completion.