Premium
Eight‐week exercise training in humans with obesity: Marked improvements in insulin sensitivity and modest changes in gut microbiome
Author(s) -
Verheggen Rebecca J. H. M.,
Konstanti Prokopis,
Smidt Hauke,
Hermus Ad R. M. M.,
Thijssen Dick H. J.,
Hopman Maria T. E.
Publication year - 2021
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.23252
Subject(s) - medicine , obesity , endocrinology , gut flora , aerobic exercise , lachnospiraceae , insulin , microbiome , firmicutes , biology , bioinformatics , immunology , 16s ribosomal rna , genetics , bacteria
Objective Obesity is associated with impaired gut microbiota diversity, which has been linked to the development of type 2 diabetes. This study aims to examine the effects of an 8‐week aerobic exercise intervention on insulin sensitivity, visceral adiposity, and gut microbiota diversity and composition in participants with obesity. Methods Fourteen participants (mean [SD], age 51 [11] years; BMI 34.9 [4.9] kg/m 2 ) performed an 8‐week exercise intervention (2 to 4 times/week on 65% to 85% of heart rate reserve). Insulin sensitivity (hyperinsulemic euglycemic clamp), cardiorespiratory fitness (maximal oxygen uptake), visceral adiposity (dual‐energy X‐ray absorptiometry scan) and gut microbiota composition (16S rRNA gene sequencing) were measured before and after the intervention. Results Insulin sensitivity showed a significant increase (pre: 3.8 [1.9] mg/min/kg; post: 4.5 [1.7] mg/min/kg; p = 0.007) after training, whereas visceral adiposity decreased (pre: 959 [361] cm 3 ; post: 897 [364] cm 3 ; p = 0.02). No change in gut microbiota α ‐ or β‐diversity was found. At the genus level, the abundance of Ruminococcus gauvreauii ( p = 0.02); Lachnospiraceae FCS020 group ( p = 0.04), and Anaerostipes ( p = 0.04) significantly increased after exercise training. Significant positive correlations were present for M‐value ( R. gauvreauii ) and VO 2 max ( R. gauvreauii and Anaerostipes ). Conclusions Eight‐week exercise training in humans with obesity leads to marked improvements in insulin sensitivity and body composition and is accompanied by modest changes in 3 gut microbiome genera, all belonging to the Firmicutes phylum.