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Phthalate and Bisphenol Urinary Concentrations, Body Fat Measures, and Cardiovascular Risk Factors in Dutch School‐Age Children
Author(s) -
Silva Carolina C. V.,
Jaddoe Vincent W. V.,
Sol Chalana M.,
El Marroun Hanan,
MartinezMoral MariaPilar,
Kannan Kurunthachalam,
Trasande Leonardo,
Santos Susana
Publication year - 2021
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.23082
Subject(s) - phthalate , body mass index , medicine , interquartile range , overweight , endocrinology , urinary system , bisphenol , blood pressure , obesity , odds ratio , blood lipids , physiology , cholesterol , chemistry , organic chemistry , epoxy
Objective The purpose of this study was to investigate the associations of urinary phthalates and bisphenols at age 6 years old with body fat and cardiovascular risk factors at 6 and 10 years and with the change from 6 to 10 years. Methods Among 471 Dutch children, the phthalates and bisphenols urinary concentrations at 6 years and BMI, fat mass index, android fat mass, blood pressure, glucose, insulin, and lipids blood concentrations at 6 and 10 years were measured. Results An interquartile range increase in di‐ n ‐octyl phthalate (DNOP) metabolites concentrations at 6 years was associated with an increased risk of overweight at 6 and 10 years (odds ratio: 1.44; 95% CI: 1.11‐1.87, and 1.43; 95% CI: 1.09‐1.86, respectively). Also, higher DNOP metabolites concentrations were associated with higher fat mass index at 6 years, higher systolic blood pressure at 10 years, a decrease in high‐density lipoprotein cholesterol, and an increase in triglycerides concentrations from 6 to 10 years ( P < 0.05). Higher total bisphenols and bisphenol A concentrations were associated with a decrease in BMI from 6 to 10 years ( P < 0.01). Conclusions DNOP metabolites are associated with overweight and an adverse cardiovascular profile in childhood. Total bisphenols and bisphenol A are associated with a decrease in BMI from 6 to 10 years.