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After‐Effects of Time‐Restricted Feeding on Whole‐Body Metabolism and Gene Expression in Four Different Peripheral Tissues
Author(s) -
Goede Paul,
Hellings Tom P.,
Coopmans Tom V.,
Ritsema Wayne I. G. R.,
Kalsbeek Andries
Publication year - 2020
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22830
Subject(s) - respiratory exchange ratio , endocrinology , gene expression , medicine , circadian rhythm , adipose tissue , biology , diabetes mellitus , physiology , gene , heart rate , blood pressure , biochemistry
Objective Epidemiological studies show that shift workers are at increased risk for type 2 diabetes. As modern societies increasingly require shift work, it seems crucial to determine whether there are long‐lasting health effects of rotational shifts. Methods This study examined the after‐effects of 4 weeks of time‐restricted feeding (TRF) during the light period (= light‐fed) in rats, an animal model for shift work. This study also included a TRF‐dark (= dark‐fed) control group. The aligned and misaligned feeding times of light and dark feeding are associated with poor and good health outcomes, respectively. Several physiological measures were monitored continuously; blood, liver, brown adipose tissue, and soleus and gastrocnemius muscle were collected following 11 days of ad libitum (AL) feeding after ending the TRF. Results In the dark‐fed animals, the day/night differences in food intake, activity, and respiratory exchange ratio were still enhanced at the end of the experiment. Light‐fed animals displayed the smallest day/night differences for these measures, as well as for body temperature. In both the light‐ and dark‐fed animals, rhythms in plasma glucose, nonesterified fatty acids, and gene expression had not fully recovered after 11 days of AL feeding. Importantly, the effects on gene expression were both tissue and gene dependent. Conclusions Our data indicate that rotational shift workers may have an increased risk of long‐lasting disturbed rhythms in several physiological measures after a period of shift work. Clearly, such disturbances may harm their health.