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Adipose Tissue Protein Glycoxidation is Associated with Weight‐Loss Potential
Author(s) -
Serrano José C. E.,
BaenaFustegueras Juan Antonio,
MartinGari Meritxell,
Rassendren Helene,
Cassanye Anna,
Naudí Alba,
LópezCano Carolina,
Sánchez Enric,
de la FuenteJuárez María Cruz,
Herrerías González Fernando,
Olsina Kissler Jorge J.,
Lecube Albert,
PorteroOtín Manuel
Publication year - 2019
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22501
Subject(s) - weight loss , adipose tissue , subcutaneous adipose tissue , medicine , obesity , diabetes mellitus , lysine , weight gain , endocrinology , subcutaneous tissue , receiver operating characteristic , surgery , body weight , chemistry , biochemistry , amino acid
Objective This study aimed to characterize the differences in protein oxidation biomarkers in adipose tissue (AT) as an indicator of AT metabolism and bariatric surgery weight‐loss success. Methods A human model, in which sixty‐five individuals with obesity underwent bariatric surgery, and a diet‐induced obesity animal model, in which animals were treated for 2 months with normocaloric diets, were analyzed to determine the associations between AT protein oxidation and body weight loss. Protein oxidative biomarkers were determined by gas chromatography/mass spectrometry in AT from human volunteers before the surgery, as well as 2 months after a diet treatment in the animal model. Results The levels of carboxyethyl‐lysine (CEL) and 2‐succinocystein (2SC) in both visceral and subcutaneous AT before the surgery directly correlated with greater weight loss in both human and animal models. 2SC levels in subcutaneous AT greater than 4.7 × 10 6 μmol/mol lysine (95% CI: 3.4 × 10 6 to 6.0 × 10 6 ) may predict greater weight loss after bariatric surgery (receiver operating characteristic curve area = 0.8222; P = 0.0047). Additionally, it was observed that individuals with diabetes presented lower levels of CEL and 2SC in subcutaneous AT ( P = 0.0266 and P = 0.0316, respectively) compared with individuals without diabetes. Conclusions CEL and 2SC in AT are useful biomarkers of AT metabolism and predict the individual's ability to reduce body weight after bariatric surgery.