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Objective  This study aimed to examine whether brown adipose tissue (BAT) or skeletal muscle activity mediates the relationship between personal level of environmental temperature (Personal‐ET) and wrist skin temperature (WT). Moreover, we examined whether BAT and skeletal muscle have a mediating role between Personal‐ET and WT (as a proxy of peripheral vasoconstriction/vasodilation).    Methods  The levels of BAT were quantified by cold‐induced  18 F‐fluorodeoxyglucose–positron emission tomography/computed tomography scan and measured the Personal‐ET and WT by using iButtons (Maxim Integrated, Dallas, Texas) in 75 participants (74.6% women).    Results  The study found that BAT volume and metabolic activity played a positive and significant role (up to 25.4%) in the association between Personal‐ET and WT. In addition, at the coldest temperatures, the participants with lower levels of WT (inducing higher peripheral vasoconstriction) had higher levels of BAT outcomes, whereas in warm temperatures, participants with higher levels of WT (inducing higher peripheral vasodilation) had lower levels of BAT outcomes. The study did not find any mediating role of skeletal muscle activity.    Conclusions  BAT volume and metabolic activity play a role in the relationship between Personal‐ET and WT. Moreover, the data suggest that there are two distinct phenotypes: individuals who respond better to the cold, both through nonshivering thermogenesis and peripheral vasoconstriction, and individuals who respond better to the heat.

The Mediating Role of Brown Fat and Skeletal Muscle Measured by 18 F‐Fluorodeoxyglucose in the Thermoregulatory System in Young Adults