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The Mediating Role of Brown Fat and Skeletal Muscle Measured by 18 F‐Fluorodeoxyglucose in the Thermoregulatory System in Young Adults
Author(s) -
MartinezTellez Borja,
AdelantadoRenau Mireia,
Acosta Francisco M.,
SanchezDelgado Guillermo,
MartinezNicolas Antonio,
Boon Mariëtte R.,
LlamasElvira Jose M.,
MartinezVizcaino Vicente,
Ruiz Jonatan R.
Publication year - 2019
Publication title -
obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.438
H-Index - 199
eISSN - 1930-739X
pISSN - 1930-7381
DOI - 10.1002/oby.22461
Subject(s) - fluorodeoxyglucose , skeletal muscle , medicine , endocrinology , nuclear medicine , positron emission tomography
Objective This study aimed to examine whether brown adipose tissue (BAT) or skeletal muscle activity mediates the relationship between personal level of environmental temperature (Personal‐ET) and wrist skin temperature (WT). Moreover, we examined whether BAT and skeletal muscle have a mediating role between Personal‐ET and WT (as a proxy of peripheral vasoconstriction/vasodilation). Methods The levels of BAT were quantified by cold‐induced 18 F‐fluorodeoxyglucose–positron emission tomography/computed tomography scan and measured the Personal‐ET and WT by using iButtons (Maxim Integrated, Dallas, Texas) in 75 participants (74.6% women). Results The study found that BAT volume and metabolic activity played a positive and significant role (up to 25.4%) in the association between Personal‐ET and WT. In addition, at the coldest temperatures, the participants with lower levels of WT (inducing higher peripheral vasoconstriction) had higher levels of BAT outcomes, whereas in warm temperatures, participants with higher levels of WT (inducing higher peripheral vasodilation) had lower levels of BAT outcomes. The study did not find any mediating role of skeletal muscle activity. Conclusions BAT volume and metabolic activity play a role in the relationship between Personal‐ET and WT. Moreover, the data suggest that there are two distinct phenotypes: individuals who respond better to the cold, both through nonshivering thermogenesis and peripheral vasoconstriction, and individuals who respond better to the heat.