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Aims   Lactobacillus  species are used widely as various food and supplements to improve health. Previous studies have shown that heat‐killed  Lactobacillus brevis   SBC 8803 induces serotonin release from intestinal cells and affects sleep rhythm and the autonomic nervous system. However, the effect of  SBC 8803 on cognitive function remains unknown. Here, we examined the effects of dietary heat‐killed  SBC 8803 on hippocampus‐dependent memory and adult hippocampal neurogenesis.    Methods  Hippocampus‐dependent memory performance was assessed in mice fed heat‐killed  SBC 8803 using social recognition and contextual fear conditioning tasks. Adult hippocampal neurogenesis was evaluated before, during, and after feeding heat‐killed  SBC 8803 by measuring the number of 5‐bromo‐2‐deoxyuridine (BrdU)‐positive cells following systemic injections of BrdU using immunohistochemistry.    Results  Mice fed a heat‐killed  SBC 8803 diet showed an improvement of hippocampus‐dependent social recognition and contextual fear memories and enhanced adult hippocampal neurogenesis by increasing the survival, but not proliferation, of newborn neurons.    Conclusion  Dietary heat‐killed  SBC 8803 functions as memory and neurogenesis enhancers.

Dietary heat‐killed Lactobacillus brevis SBC 8803 ( SBL 88™) improves hippocampus‐dependent memory performance and adult hippocampal neurogenesis