English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Aim  Tryptophan hydroxylase 2 (Tph2) is a rate‐limiting enzyme for the biosynthesis of 5‐hydroxytryptamine (5‐ HT , serotonin). Previous studies have reported that C1473G polymorphism of the murine  Tph2  gene leads to decreased 5‐ HT  levels in the brain and abnormal behavioral phenotypes, such as impaired anxiety‐ and depression‐like behaviors. In this study, to confirm the effect of the C1473G polymorphism on mouse phenotypes, we conducted a comprehensive battery of behavioral tests and measured the amounts of brain free amino acids involved in the production of 5‐ HT .    Methods  We obtained C57 BL /6J congenic mice that were homozygous for the 1473G allele of  Tph2  (1473G) and subjected them and their wild‐type littermates (1473C) to a battery of behavioral tests. Using reverse‐phase high‐performance liquid chromatography ( HPLC ), we measured the amounts of free amino acids in the 5‐ HT  and epinephrine synthetic/metabolic pathways in the frontal cortex, hippocampus, striatum, and midbrain.    Results  We failed to detect significant differences between genotypes in depression‐like behaviors, anxiety‐like behaviors, social behaviors, sensorimotor gaiting, or learning and memory, while 1473G mice exhibited a nominally significant impairment in gait analysis, which failed to reach study‐wide significance. In the  HPLC  analysis, there were no significant differences in the amounts of 5‐ HT , dopamine, norepinephrine, and epinephrine in the frontal cortex, hippocampus, striatum, and midbrain.    Conclusion  Our findings do not support the idea that congenic C57 BL /6J mice carrying the 1473G allele may represent an animal model of mood disorder under normal conditions without stress.

neuropsychopharmacology reports

Comprehensive behavioral analysis and quantification of brain free amino acids of C57 BL /6J congenic mice carrying the 1473G allele in tryptophan hydroxylase‐2