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Aim  Interleukin‐17A ( IL ‐17A) plays an essential role in tissue inflammation by inducing proinflammatory cytokine and chemokine production and is related to innate immune reactions.  IL ‐17A also contributes to neuroinflammation, neuropathic pain, and mechanical hypersensitivity after peripheral nerve injury in rodents. To clarify the contribution of  IL ‐17A to pain‐related phenotypes in humans, we investigated the association between pain‐related phenotypes and the rs2275913 single‐nucleotide polymorphism ( SNP ) of the   IL ‐17A  gene, which has been reported to be associated with rheumatoid arthritis, ulcerative colitis, and some cancers.    Methods  The present study used a correlational design to examine the impact of the rs2275913  SNP  on postoperative pain‐related phenotypes in a group of patients who underwent cosmetic orthognathic surgery.    Results  Carriers of the  AA  genotype had higher opioid requirements during and after surgery than carriers of the  AG  and  GG  genotypes ( P  = .009). Linear regression analysis indicated that opioid requirements linearly increased as the copy number of the A allele of the  SNP  increased ( P  = .008).    Conclusions  Opioid requirements during and after surgery are enhanced in carriers of the  AA  genotype of the rs2275913  SNP  of the   IL ‐17A  gene, possibly through an enhancement of  IL ‐17A function that induces inflammation that is related to the inflammatory pain stimulus.

neuropsychopharmacology reports

Association between rs2275913 single‐nucleotide polymorphism of the  interleukin‐17A  gene and perioperative analgesic use in cosmetic orthognathic surgery