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A brain MRI study of chronic fatigue syndrome: evidence of brainstem dysfunction and altered homeostasis
Author(s) -
Barnden Leighton R.,
Crouch Benjamin,
Kwiatek Richard,
Burnet Richard,
Mer Anacleto,
Chryssidis Steve,
Scroop Garry,
Del Fante Peter
Publication year - 2011
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1692
Subject(s) - brainstem , white matter , grey matter , cardiology , midbrain , hemodynamics , medicine , psychology , cerebral blood flow , neuroscience , magnetic resonance imaging , central nervous system , radiology
Voxel‐wise regressions of MRI levels versus clinical scores in chronic fatigue syndrome (CFS) suggested volume loss in the midbrain, and altered homeostasis in the brain stem, prefrontal white matter and the hypothalamus. The effect of an insult to the midbrain at onset may persist and disrupt multiple feedback loops.