Premium
Effects of repeated abobotulinumtoxinA injections in upper limb spasticity
Author(s) -
Gracies JeanMichel,
O'Dell Michael,
Vecchio Michele,
Hedera Peter,
Kocer Serdar,
RudzinskaBar Monika,
Rubin Bruce,
Timerbaeva Sofiya L.,
Lusakowska Anna,
Boyer François Constant,
Grandoulier AnneSophie,
Vilain Claire,
Picaut Philippe
Publication year - 2018
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25721
Subject(s) - medicine , spasticity , elbow , upper limb , muscle tone , adverse effect , wrist , physical medicine and rehabilitation , population , anesthesia , repeated measures design , physical therapy , incidence (geometry) , surgery , statistics , physics , environmental health , mathematics , optics
: The efficacy of single injections of abobotulinumtoxinA (Dysport) is established in adults with upper limb spasticity. In this study we assessed the effects of repeated injections of abobotulinumtoxinA over 1 year. Methods : Patients ( n = 258, safety population) received 500 U, 1,000 U, or 1,500 U (1,500‐U dose included 500‐U shoulder injections) for up to 4 or 5 treatment cycles. Assessments included treatment‐emergent adverse events (TEAEs), muscle tone, passive and active range of motion (X V1, X A ), angle of catch (X V3 ), Disability Assessment Scale (DAS) score, Modified Frenchay Scale (MFS) score, and Physician Global Assessment (PGA) score. Results : The incidence of TEAEs decreased across cycles. Muscle tone reduction and X V1 remained stable across cycles, whereas X V3 and X A continued to improve at the finger, wrist, and elbow flexors. DAS and PGA improved across cycles. MFS improved best with 1,500 U. Discussion : A favorable safety profile and continuous improvements in active movements and perceived and active function were associated with repeated abobotulinumtoxinA injections in upper limb muscles. Muscle Nerve 57 : 245–254, 2018