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Purpose  Dual‐velocity encoded (dual‐venc or DV) 4D flow MRI achieves wide velocity dynamic range and velocity‐to‐noise ratio (VNR), enabling accurate neurovascular flow characterization. To reduce scan time, we present interleaved dual‐venc 4D Flow with independently prescribed, prospectively undersampled spatial resolution of the high‐venc (HV) acquisition: Variable Spatial Resolution Dual Venc (VSRDV).    Methods  A prototype VSRDV sequence was developed based on a Cartesian acquisition with eight‐point phase encoding, combining PEAK‐GRAPPA acceleration with zero‐filling in phase and partition directions for HV. The VSRDV approach was optimized by varying  z , the zero‐filling fraction of HV relative to low‐venc, between 0%–80% in vitro (realistic neurovascular model with pulsatile flow) and in vivo ( n  = 10 volunteers). Antialiasing precision, mean and peak velocity quantification accuracy, and test–retest reproducibility were assessed relative to reference images with equal‐resolution HV and low venc ( z  = 0%).    Results  In vitro results for all  z  demonstrated an antialiasing true positive rate at least 95% forR   PEAK  −  GRAPPA$$ {R}_{\mathrm{PEAK}-\mathrm{GRAPPA}} $$    = 2 and 5, with no linear relationship to  z  ( p  = 0.62 and 0.13, respectively). Bland–Altman analysis for  z  = 20%, 40%, 60%, or 80% versus  z  = 0% in vitro and in vivo demonstrated no bias >1% of venc in mean or peak velocity values at anyR  ZF    $$ {R}_{\mathrm{ZF}} $$   . In vitro mean and peak velocity, and in vivo peak velocity, had limits of agreement within 15%.    Conclusion  VSRDV allows up to 34.8% scan time reduction compared to PEAK‐GRAPPA accelerated DV 4D Flow MRI, enabling large spatial coverage and dynamic range while maintaining VNR and velocity measurement accuracy.

Accelerated dual‐venc 4D flow MRI with variable high‐venc spatial resolution for neurovascular applications