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Purpose  Current challenges of  in vivo  CEST imaging include overlapping signals from different pools. The overlap arises from closely resonating pools and/or the broad magnetization transfer contrast (MTC) from macromolecules. This study aimed to evaluate the feasibility of variable delay multipulse (VDMP) CEST to separately assess solute pools with different chemical exchange rates in the human brain  in vivo , while mitigating the MTC.    Methods  VDMP saturation buildup curves were simulated for amines, amides, and relayed nuclear Overhauser effect. VDMP data were acquired from glutamate and bovine serum albumin phantoms, and from six healthy volunteers at 7T. For the  in vivo  data, MTC removal was performed via a three‐pool Lorentzian fitting. Different B 1  amplitudes and mixing times were used to evaluate CEST pools with different exchange rates.    Results  The results show the importance of removing MTC when applying VDMP  in vivo  and the influence of B 1  for distinguishing different pools. Finally, the optimal B 1  and mixing times to effectively saturate slow‐ and fast‐exchanging components are also reported. Slow‐exchanging amides and rNOE components could be distinguished when using B 1  = 1 μT and t mix  = 10 ms and 40 ms, respectively. Fast‐exchanging components reached the highest saturation when using a B 1  = 2.8 μT and t mix  = 0 ms.    Conclusion  VDMP is a powerful CEST‐editing tool, exploiting chemical exchange‐rate differences. After MTC removal, it allows separate assessment of slow‐ and fast‐exchanging solute pools in  in vivo  human brain.

The use of variable delay multipulse chemical exchange saturation transfer for separately assessing different CEST pools in the human brain at 7T