English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Purpose  To assess the effects of blip‐up and ‐down echo planar imaging (EPI) acquisition designs, with different choices of phase‐encoding directions (PEDs) on the reproducibility of diffusion MRI (dMRI)‐derived metrics in the human brain.    Methods  Diffusion MRI data in seven subjects were acquired five times, each with five different protocols. The base design included 64 diffusion directions acquired with anterior‐posterior (AP) PED, the first and second protocols added reverse phase‐encoded    b  =  0    s  /   mm  2posterior‐anterior (PA) PED images. The third one included 32 directions all with PED acquisitions with opposite polarity (AP and PA). The fourth protocol, also with 32 unique directions used four PEDs (AP, PA, right‐left (RL), and left‐right (LR)). The scan time was virtually identical for all protocols. The variability of diffusion MRI metrics for each subject and each protocol was computed across the different sessions.    Results  The highest reproducibility for all dMRI metrics was obtained with protocol four (AP/PA‐RL/LR, ie, four‐way PED). Protocols that used only    b  =  0    s  /   mm  2for distortion correction, which are the most widely used designs, had the lowest reproducibility.    Conclusions  An acquisition design with four PEDs, including all DWIs in addition to    b  =  0    s  /   mm  2images should be used to achieve high reproducibility in diffusion MRI studies.

Improved reproducibility of diffusion MRI of the human brain with a four‐way blip‐up and down phase‐encoding acquisition approach