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Purpose  To develop a single‐shot multi‐slice    T  1    mapping method by combing simultaneous multi‐slice (SMS) excitations, single‐shot inversion‐recovery (IR) radial fast low‐angle shot (FLASH), and a nonlinear model–based reconstruction method.    Methods  SMS excitations are combined with a single‐shot IR radial FLASH sequence for data acquisition. A previously developed single‐slice calibrationless model–based reconstruction is extended to SMS, formulating the estimation of parameter maps and coil sensitivities from all slices as a single nonlinear inverse problem. Joint‐sparsity constraints are further applied to the parameter maps to improve    T  1    precision. Validations of the proposed method are performed for a phantom and for the human brain and liver in 6 healthy adult subjects.    Results  Phantom results confirm good    T  1    accuracy and precision of the simultaneously acquired multi‐slice    T  1    maps in comparison to single‐slice references. In vivo human brain studies demonstrate the better performance of SMS acquisitions compared to the conventional spoke‐interleaved multi‐slice acquisition using model‐based reconstruction. Aside from good accuracy and precision, the results of 6 healthy subjects in both brain and abdominal studies confirm good repeatability between scan and re‐scans. The proposed method can simultaneously acquire    T  1    maps for 5 slices of a human brain (   0.75  ×  0.75  ×  5mm  3    ) or 3 slices of the abdomen (   1.25  ×  1.25  ×  6mm  3    ) within 4 seconds.    Conclusions  The IR SMS radial FLASH acquisition together with a nonlinear model–based reconstruction enable rapid high‐resolution multi‐slice    T  1    mapping with good accuracy, precision, and repeatability.

Model‐based reconstruction for simultaneous multi‐slice T 1 mapping using single‐shot inversion‐recovery radial FLASH