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Purpose  Arterial transit time uncertainties and challenges during planning are potential issues for renal perfusion measurement using spatially selective arterial spin labeling techniques. To mitigate these potential issues, a spatially non‐selective technique, such as velocity‐selective arterial spin labeling (VSASL), could be an alternative. This article explores the influence of VSASL sequence parameters and respiratory induced motion on VS‐label generation.    Methods  VSASL data were acquired in human subjects ( n  = 15), with both single and dual labeling, during paced‐breathing, while essential sequence parameters were systematically varied; (1) cutoff velocity, (2) labeling gradient orientation and (3) post‐labeling delay (PLD). Pseudo‐continuous ASL was acquired as a spatially selective reference. In an additional free‐breathing single VSASL experiment ( n  = 9) we investigated respiratory motion influence on VS‐labeling. Absolute renal blood flow (RBF), perfusion weighted signal (PWS), and temporal signal‐to‐noise ratio (tSNR) were determined.    Results  (1) With decreasing cutoff velocity, tSNR and PWS increased. However, undesired tissue labeling occurred at low cutoff velocities (≤ 5.4 cm/s). (2) Labeling gradient orientation had little effect on tSNR and PWS. (3) For single VSASL high signal appeared in the kidney pedicle at PLD < 800 ms, and tSNR and PWS decreased with increasing PLD. For dual VSASL, maximum tSNR occurred at PLD = 1200 ms. Average cortical RBF measured with dual VSASL (264 ± 34 mL/min/100 g) at a cutoff velocity of 5.4 cm/s, and feet‐head labeling was slightly lower than with pseudo‐continuous ASL (283 ± 55 mL/min/100 g).    Conclusion  With well‐chosen sequence parameters, tissue labeling induced by respiratory motion can be minimized, allowing to obtain good quality RBF maps using planning‐free labeling with dual VSASL.

Influence of labeling parameters and respiratory motion on velocity‐selective arterial spin labeling for renal perfusion imaging