English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Purpose  To systematically analyze intravoxel incoherent motion (IVIM) MRI in a perfusable capillary phantom closely matching the geometry of capillary beds in vivo and to compare the validity of the biexponential pseudo‐diffusion and the recently introduced phase‐distribution IVIM model.    Methods  IVIM‐MRI was performed at 12 different flow rates (   0.2  ⋯  2.4    m  L  /   min    ) in a capillary phantom using 4 different DW‐MRI sequences (2 with monopolar and 2 with flow‐compensated diffusion‐gradient schemes, with up to   16b   values between   0   and    800    s  /    mm   2    ). Resulting parameters from the assessed IVIM models were compared to results from optical microscopy.    Results  The acquired data were best described by a static and a flowing compartment modeled by the phase‐distribution approach. The estimated signal fraction   f   of the flowing compartment stayed approximately constant over the applied flow rates, with an average of    f    =    0.451    ±    0.023    in excellent agreement with optical microscopy (   f  =  0.454    ±    0.002   ). The estimated average particle flow speeds    v  =  0.25  ⋯  2.7mm   /  s    showed a highly significant linear correlation to the applied flow. The estimated capillary segment length of approximately    189  u  m    agreed well with optical microscopy measurements. Using the biexponential model, the signal fraction   f   was substantially underestimated and displayed a strong dependence on the applied flow rate.    Conclusion  The constructed phantom facilitated the detailed investigation of IVIM‐MRI methods. The results demonstrate that the phase‐distribution method is capable of accurately characterizing fluid flow inside a capillary network. Parameters estimated using the biexponential model, specifically the perfusion fraction   f  , showed a substantial bias because the model assumptions were not met by the underlying flow pattern.

Assessment of intravoxel incoherent motion MRI with an artificial capillary network: analysis of biexponential and phase‐distribution models