Premium
Reproducibility of 2 D G lu CEST in healthy human volunteers at 7 T
Author(s) -
Nanga Ravi Prakash Reddy,
DeBrosse Catherine,
Kumar Dushyant,
Roalf David,
McGeehan Brendan,
D'Aquilla Kevin,
Borthakur Arijitt,
Hariharan Hari,
Reddy Damodara,
Elliott Mark,
Detre John A.,
Epperson Cynthia Neill,
Reddy Ravinder
Publication year - 2018
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.27362
Subject(s) - reproducibility , white matter , coefficient of variation , nuclear medicine , glutamate receptor , medicine , magnetic resonance imaging , chemistry , nuclear magnetic resonance , radiology , chromatography , physics , receptor
Purpose To investigate the reproducibility of gray and white matter glutamate contrast of a brain slice among a small group of healthy volunteers by using the 2D single‐slice glutamate CEST (GluCEST) imaging technique. Methods Six healthy volunteers were scanned multiple times for within‐day and between‐day reproducibility. One more volunteer was scanned for within‐day reproducibility at 7T MRI. Glutamate CEST contrast measurements were calculated for within subjects and among the subjects and the coefficient of variations are reported. Results The GluCEST measurements were highly reproducible in the gray and white matter area of the brain slice, whether it was within‐day or between‐day with a coefficient of variation of less than 5%. Conclusion This preliminary study in a small group of healthy volunteers shows a high degree of reproducibility of GluCEST MRI in brain and holds promise for implementation in studying age‐dependent changes in the brain.