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Simultaneous multislice acquisition without trajectory modification for hyperpolarized 13 C experiments
Author(s) -
Lau Angus Z.,
Lau Justin Y. C.,
Chen Albert P.,
Cunningham Charles H.
Publication year - 2018
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.27136
Subject(s) - multislice , imaging phantom , scanner , nuclear magnetic resonance , pulse sequence , image resolution , physics , image quality , acceleration , nuclear medicine , spiral (railway) , optics , iterative reconstruction , biomedical engineering , materials science , computer science , artificial intelligence , image (mathematics) , mathematics , medicine , mathematical analysis , classical mechanics
Purpose To investigate the feasibility of performing large FOV hyperpolarized 13 C metabolic imaging using simultaneous multislice excitation. Methods A spectral‐spatial multislice excitation pulse was constructed by cosine modulation and incorporated into a 13 C spiral imaging sequence. Phantom and in vivo pig experiments were performed to test the feasibility of simultaneous multislice data acquisition and image reconstruction. In vivo cardiac‐gated images of hyperpolarized pyruvate, bicarbonate, and lactate were obtained at 1 × 1 × 1 cm 3 resolution over a 48 × 48 × 24 cm 3 FOV with 2‐fold acceleration in the slice direction. Sensitivity encoding was used for image reconstruction with both autocalibrated and numerically calculated coil sensitivities. Results Simultaneous multislice images obtained with 2‐fold acceleration were comparable to reference unaccelerated images. Retained SNR figures greater than 80% were achieved over the part of the image containing the heart. Conclusion This method is anticipated to enable large FOV imaging studies using hyperpolarized 13 C substrates, with an aim toward whole‐body exams that have to date been out of reach.