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Perfusion imaging of the human brain at 1.5 T using a single‐shot EPI spin tagging approach
Author(s) -
Ye Frank Q.,
Pekar James J.,
Jezzard Peter,
Duyn Jeff,
Frank Joseph A.,
McLaughlin Alan C.
Publication year - 1996
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910360208
Subject(s) - cerebral blood flow , arterial spin labeling , blood flow , single shot , nuclear medicine , artifact (error) , perfusion , perfusion scanning , medicine , nuclear magnetic resonance , biomedical engineering , radiology , computer science , cardiology , physics , artificial intelligence , optics
Abstract Single‐shot echo planar imaging (EPI) techniques have been applied, in conjunction with arterial spin tagging approaches, to obtain images of cerebral blood flow in a single axial slice in the human brain. Serial studies demonstrate that cerebral blood flow images acquired in 8 min are reproducible, with a statistical precision of approximately ±10 cc/100 g/min. The average value of cerebral blood flow in the slice is 51 ±11 cc/100 g/min for six normal subjects. The cerebral blood flow images contain two types of artifact, probably due to arterial and venous blood volume contributions, which must be overcome before the arterial spin tagging approach can be used for routine clinical studies.