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Magnetic resonance biomarkers in radiation oncology: The report of AAPM Task Group 294
Author(s) -
McGee Kiaran P.,
Hwang KenPin,
Sullivan Daniel C.,
Kurhanewicz John,
Hu Yanle,
Wang Jihong,
Li Wen,
Debbins Josef,
Paulson Eric,
Olsen Jeffrey R.,
Hua Chiaho,
Warner Lizette,
Ma Daniel,
Moros Eduardo,
Tyagi Neelam,
Chung Caroline
Publication year - 2021
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1002/mp.14884
Subject(s) - context (archaeology) , biomarker , medicine , radiation therapy , magnetic resonance imaging , medical physics , radiation oncology , personalized medicine , oncology , bioinformatics , radiology , biology , paleontology , biochemistry
Purpose A magnetic resonance (MR) biologic marker (biomarker) is a measurable quantitative characteristic that is an indicator of normal biological and pathogenetic processes or a response to therapeutic intervention derived from the MR imaging process. There is significant potential for MR biomarkers to facilitate personalized approaches to cancer care through more precise disease targeting by quantifying normal versus pathologic tissue function as well as toxicity to both radiation and chemotherapy. Both of which have the potential to increase the therapeutic ratio and provide earlier, more accurate monitoring of treatment response. The ongoing integration of MR into routine clinical radiation therapy (RT) planning and the development of MR guided radiation therapy systems is providing new opportunities for MR biomarkers to personalize and improve clinical outcomes. Their appropriate use, however, must be based on knowledge of the physical origin of the biomarker signal, the relationship to the underlying biological processes, and their strengths and limitations. The purpose of this report is to provide an educational resource describing MR biomarkers, the techniques used to quantify them, their strengths and weakness within the context of their application to radiation oncology so as to ensure their appropriate use and application within this field.