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We explore a mechanism of pattern formation arising in processes described by a system of a single reaction–diffusion equation coupled with ordinary differential equations. Such systems of equations arise from the modeling of interactions between cellular processes and diffusing growth factors. We focus on the model of early carcinogenesis proposed by Marciniak‐Czochra and Kimmel, which is an example of a wider class of pattern formation models with an autocatalytic non‐diffusing component. We present a numerical study showing emergence of periodic and irregular spike patterns because of diffusion‐driven instability. To control the accuracy of simulations, we develop a numerical code on the basis of the finite‐element method and adaptive mesh grid. Simulations, supplemented by numerical analysis, indicate a novel pattern formation phenomenon on the basis of the emergence of nonstationary structures tending asymptotically to a sum of Dirac deltas. Copyright © 2013 John Wiley & Sons, Ltd.

Spike patterns in a reaction–diffusion ODE model with Turing instability