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Longitudinal Tau Positron Emission Tomography in Dementia with Lewy Bodies
Author(s) -
Chen Qin,
Przybelski Scott A.,
Senjem Matthew L.,
Schwarz Christopher G.,
Lesnick Timothy G.,
Botha Hugo,
Knopman David S.,
GraffRadford Jonathan,
Savica Rodolfo,
Jones David T.,
Fields Julie A.,
Jain Manoj K.,
GraffRadford Neill R.,
Ferman Tanis J.,
Kremers Walter K.,
Jack Clifford R.,
Petersen Ronald C.,
Boeve Bradley F.,
Lowe Val J.,
Kantarci Kejal
Publication year - 2022
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28973
Subject(s) - dementia with lewy bodies , standardized uptake value , dementia , atrophy , positron emission tomography , occipital lobe , magnetic resonance imaging , alzheimer's disease , nuclear medicine , medicine , temporal lobe , psychology , neuroimaging , hippocampus , neuroscience , radiology , disease , epilepsy
Background and Objective Patients with dementia with Lewy bodies (DLB) may have overlapping Alzheimer's disease pathology. We investigated the longitudinal rate of tau accumulation and its association with neurodegeneration and clinical disease progression in DLB. Methods Consecutive patients with probable DLB (n = 22) from the Mayo Clinic Alzheimer's Disease Research Center and age‐matched and sex‐matched cognitively unimpaired controls (CU; n = 22) with serial magnetic resonance imaging and flortaucipir positron emission tomography scans within an average of 1.6 years were included. Regional annualized rates of flortaucipir uptake standardized uptake value ratios (SUVr) were calculated. Regional annualized rates of cortical volume change were measured with the Tensor Based Morphometry–Syn algorithm. Results The annual increase of flortaucipir SUVr was greater in the middle and superior occipital, fusiform, and inferior parietal cortices in DLB (mean: 0.017, 0.019, 0.019, and 0.015, respectively) compared with the CU (mean: −0.006, −0.009, −0.003, and − 0.005, respectively; P < 0.05). In patients with DLB (but not the CU), a longitudinal increase in flortaucipir SUVr was associated with longitudinal cortical atrophy rates in the lateral occipital and inferior temporoparietal cortices, hippocampus, and the temporal pole as well as a concurrent decline on Mini‐Mental State Examination and Clinical Dementia Rating–Sum of Boxes in the lateral occipital and the fusiform cortices. Conclusions Tau accumulation was faster in DLB compared with the CU, with increased accumulation rates in the lateral occipital and temporoparietal cortices. These increased rates of tau accumulation were associated with neurodegeneration and faster disease progression in DLB. Tau may be a potential treatment target in a subset of patients with DLB. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society